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Pradeep Kachroo PradeepKachroowasborninIndia,wherehereceivedhisB.S.degreeattheUniversityofDelhiin1987andhisM.S.andPh.D.degreesattheUniversityofBarodain1989and1995,respectively.AportionofhisdissertationresearchwasconductedattheUniversityofWisconsin,Madison,throughagraduatefellowshipfromtheRockefellerFoundation.Heconductedresearchasapost-doctoralscholarattheSwissFederalInstituteofTechnology(ETH)inZurich,theWaksmanInstituteofMicrobiologyatRutgersUniversity,andtheBoyceThompsonInstituteatCornellUniversity.KachroojoinedthefacultyoftheUniversityofKentuckyintheDepartmentofPlantPathologyin2002andwaspromotedtoassociateprofessorwithtenurein2007andtofullprofessorin2013.Kachroostudiesoneofthegreatenigmasinbiology,onethatpertainsnotonlytoplantsandtheirpathogens,whichishisfocus,butalsotoanimals,includinghumans,andtheircausalagentsofdisease.Namely,how,intermsofbiochemical,genetic,andmolecularmechanisms,doesanindividualcellorawholeorganismperceivethatitisunderattack?Whatpathwaysdosignalsfollowtoactivateresponsesnormal
Wenbo Ma Shestudiesthemolecularmechanismsunderlyingmicrobialpathogenesis.Inparticular,sheinterestedinelucidatingthestrategiesemployedbybacteriaandoomycetepathogenstofacilitatetheestablishmentandmaintenanceofsymbioticrelationshipwithplanthosts.Acombinationofcomparativegenomic,functionalgenomic,genetic,biochemicalandbioinformaticapproachesisutilizedtoaccomplishthesegoals.Novelknowledgeobtainedfromourresearchwillcontributetothedevelopmentofsustainablecontrolstrategiesagainstthesedestructiveplantdiseases.Themainfocusofherresearchisagroupofspecializedvirulenceproteins,calledeffectors,whicharesecretedfromthepathogensanddirectlymanipulatespecificphysiologicalprocessesorsignalingpathwaysinhostcellsforthebenefitofinfection.Abroadrangeofparasites,includingviruses,bacteria,fungi,oomycetes,protozoa,insectsandnematodes,subverthostimmunitythroughthefunctionsofeffectors.SheisworkingonthetypeIIIeffectorsofbacterialpathogensandtheRxLReffectorsofPhytophthorapathogenstounderstandtheirfunctionsandevolutionduringth
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