欧阳颀，中国科学院院士

浙江大学物理高等研究院复杂与生命系统物理研究中心主任。

教育经历：

1983-11至1989-02，法国波尔多第一大学，物理化学，博士

1978-09至1982-06，清华大学，化学与化学工程，学士

工作经历：

2024-01至今，浙江大学，物理学院，教授

1998-05至2024-01，北京大学，物理学院，教授

1996-06至1998-04，日本电器公司，NECI，研究员

1995-06至1996-05，法国尼斯非线性中心，NDLN，研究员

1989-03至1995-05，美国德克萨斯大学奥斯丁分校，博士后

研究方向：

欧阳颀院士课题组主要应用非线性动力学、复杂系统理论、统计物理的概念以及微流控实验技术，研究方法探索生物控制网络的特性，包括网络拓扑学特性，网络动力学特性，网络功能特性，以及三种特性之间的相互制约关系，并试图将研究中所总结的规律应用到合成生物学领域。

研究成果：

1. Zhang Y, Ouyang Q, Tu Y. Geometry of Optimal Control in Chemical Reaction Networks in the Adiabatic Limit. [J]. Physical review letters, 2025, 134 (1): 018001.

2. Chen K, Rong N, Zhang C, Xu, J,He H, Liu WY, Xu YJ, Wu YZ, Ouyang Q, Zhou YL, Yu YJ, Yang W, Luo CX. A Multi‐Volume Microfluidic Device for Automated and Wide Dynamic Range Digital LAMP Applications[J]. Advanced Materials Technologies, 2025,10:2401366.

3. Yuqi Ma, Xiaoyi Sun, Ziwei Cai, Mengjing Tu, Yugang Wang, Qi Ouyang, Xueqing Yan, Gaoshan Jing, Gen Yang. Transformation gap from research findings to large-scale commercialized products in microfluidic field[J]. Materials Today Bio, 2024, 29 101373-101373.

4. Haochen Fu, Chenyi Fei, Qi Ouyang, Yuhai Tu. Temperature compensation through kinetic regulation in biochemical oscillators.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (21): e2401567121-e2401567121.

5. Chenrui Qin, Tong Xu, Xuejin Zhao, Yeqing Zong, Haoqian M. Zhang, Chunbo Lou, Qi Ouyang, Long Qian. Functional predictability of universal gene circuits in diverse microbial hosts[J]. Quantitative Biology, 2024, 12 (2): 129-140.

6. Wei Fu, Shujing Wang, Qi Ouyang, Chunxiong Luo. A multilayer microfluidic system for studies of the dynamic responses of cellular proteins to oxygen switches at the single-cell level.[J]. Integrative biology : quantitative biosciences from nano to macro, 2024, 16.

7. Yanhong Sun, Fengyu Zhang, Qi Ouyang, Chunxiong Luo. The dynamic-process characterization and prediction of synthetic gene circuits by dynamic delay model[J]. iScience, 2024, 27 (3): 109142-.

8. Mengze Gan,Jinge Cao,Yandi Zhang,Hui Fu,Xiaosong Lin,Qi Ouyang,Xinyue Xu,Yin Yuan,Xionglin Fan.Landscape of T cell epitopes displays hot mutations of SARS-CoV-2 variant spikes evading cellular immunity.[J].Journal of medical virology, 2024, 96(2):e29452-e29452.

9. Cheng Zhang, Ranfeng Wu, Fajia Sun, Yisheng Lin, Yuan Liang, Jiongjiong Teng, Na Liu, Qi Ouyang, Long Qian, Hao Yan. Parallel molecular data storage by printing epigenetic bits on DNA[J]. Nature, 2024, 634 (8035): 824-832.

10. Li D, Liao S, Ouyang Q, et al. Interplay between ATP and hydrolysis free energy in promoting and restraining biochemical switches[J]. Physical Review Research, 2024, 6(3): 033050.

11. Donghoon L ,Yanan Z ,Louis C , et al. Molecular mechanism for activation of the 26S proteasome by ZFAND5. [J]. Molecular cell, 2023, 83 (16): 2959-2975.e7.

12. Han Xu, Zhang Dongliang, Hong Lu, Yu Daqi, Wu Zhaolong, Yang Tian, Rust Michael, Tu Yuhai, Ouyang Qi. Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex.[J]. Nature communications, 2023, 14 (1): 5907-5907.

13. Zhou Zhengqing, Li Dianjie, Zhao Ziheng, Shi Shuyu, Wu Jianghua, Li Jianwei, Zhang Jingpeng, Gui Ke, Zhang Yu, Ouyang Qi, Mei Heng, Hu Yu, Li Fangting. Dynamical modelling of viral infection and cooperative immune protection in COVID-19 patients.[J]. PLoS computational biology, 2023, 19 (9): e1011383-e1011383.

14. Zhang Chi, Ouyang Qi, Zhou Xianyuan, Huang Yingfeng, Zeng Yu, Deng Li, Lin Dachuan, Zheng Weidong. In vitro activity of tetracycline analogs against multidrug-resistant and extensive drug resistance clinical isolates of Mycobacterium tuberculosis[J]. Tuberculosis, 2023, 140 102336-102336.

15. Chen Xinmao, Wang Tianze, Guan Ying, Ouyang Qi, Lou Chunbo, Qian Long. The Topological Characteristics of Biological Ratio-Sensing Networks[J]. Life, 2023, 13 (2): 351-351.

16. Sun Fajia, Dong Yiming, Ni Ming, Ping Zhi, Sun Yuhui, Ouyang Qi, Qian Long. Mobile and Self-Sustained Data Storage in an Extremophile Genomic DNA.[J]. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023,10(10): e2206201-e2206201.

17. Shi J, Xu J, Yu Y, Yu YJ, Wu CY, Chen JN, Li, SS, Ouyang Q, Yang W, Luo CX. A Parallelable 3D Microfluidic Chip for Circulating‐Tumor‐Cell Capture at Ultra‐High Throughput and Wide Flow Rate Range[J]. Advanced NanoBiomed Research, 2023, 3(5): 2200140.

18. Li Feng, Yang JingJing, Sun ZongYi, Wang Lei, Qi LeYao, A Sina, Liu YiQun, Zhang HongMei, Dang LeiFan, Wang ShuJing, Luo ChunXiong, Nian WeiFeng, O'Conner Seth, Ju LongZhen, Quan WeiPeng, Li XiaoKang, Wang Chao, Wang DePeng, You HanLi, Cheng ZhuKuan, Yan Jia, Tang FuChou, Yang DeChang, Xia ChuWei, Gao Ge, Wang Yan, Zhang BaoCai, Zhou YiHua, Guo Xing, Xiang SunHuan, Liu Huan, Peng TianBo, Su XiaoDong, Chen Yong, Ouyang Qi, Wang DongHui, Zhang DaMing, Xu ZhiHong, Hou HongWei, Bai ShuNong, Li Ling. Plant-on-chip: Core morphogenesis processes in the tiny plant Wolffia australiana.[J]. PNAS nexus, 2023, 2 (5): pgad141-pgad141.

19. Qin Chenrui, Xiang Yanhui, Liu Jie, Zhang Ruilin, Liu Ziming, Li Tingting, Sun Zhi, Ouyang Xiaoyi, Zong Yeqing, Zhang Haoqian M, Ouyang Qi, Qian Long, Lou Chunbo. Precise programming of multigene expression stoichiometry in mammalian cells by a modular and programmable transcriptional system.[J]. Nature communications, 2023, 14 (1): 1500-1500.

20. Shen Wenting, Gao Ziqing, Chen Kaiyue, Zhao Alusi, Ouyang Qi, Luo Chunxiong. The regulatory mechanism of the yeast osmoresponse under different glucose concentrations[J]. iScience, 2023, 26 (1): 105809-105809.

21. Chen Xinmao, Liu Ziming, Lou Chunbo, Guan Ying, Ouyang Qi, Xiang Yanhui. Improving cooperativity of transcription activators by oligomerization domains in mammalian cells[J]. Synthetic and Systems Biotechnology, 2023, 8 (1): 114-120.

22. Rong Nan, Chen Kaiyue, Shao Jiqi, Ouyang Qi, Luo Chunxiong. A 3D Scalable Chamber-Array Chip for Digital LAMP.[J]. Analytical chemistry, 2023, 95 (20):

23. Wang ZhaoXi, Liu Bing, Yang Tian, Yu Daqi, Zhang Chu, Zheng Liming, Xie Jin, Liu Bin, Liu Mengxi, Peng Hailin, Lai Luhua, Ouyang Qi, Ouyang Songying, Zhang YongAn. Structure of the Spring Viraemia of Carp Virus Ribonucleoprotein Complex Reveals Its Assembly Mechanism and Application in Antiviral Drug Screening.[J]. Journal of virology, 2023, 97 (4): e0182922-e0182922.

24. Zhang Jing, Shen Wenting, Cai Zhiyuan, Chen Kaiyue, Ouyang Qi, Wei Ping, Yang Wei, Luo Chunxiong. Microfluidic-Enabled Multi-Cell-Densities-Patterning and Culture Device for Characterization of Yeast Strains’ Growth Rates under Mating Pheromone[J]. Chemosensors, 2022, 10 (4): 141-141.

25. Zhou Jiaxin, Wang Hongli, Ouyang Qi. Network rewiring and plasticity promotes synchronization of suprachiasmatic nucleus neurons.[J]. Chaos (Woodbury, N.Y.), 2022, 32 (2): 023101-023101.

26. Sun Yanhong, Zhang Fengyu, Li Lusi, Chen Kaiyue, Wang Shujing, Ouyang Qi, Luo Chunxiong. Two-Layered Microfluidic Devices for High-Throughput Dynamic Analysis of Synthetic Gene Circuits in E. coli.[J]. ACS synthetic biology, 2022, 11 (12):

27. Guan Ying, Chen Xinmao, Shao Bin, Ji Xiangyu, Xiang Yanhui, Jiang Guoqiang, Xu Lina, Lin Zhanglin, Ouyang Qi, Lou Chunbo. Mitigating Host Burden of Genetic Circuits by Engineering Autonegatively Regulated Parts and Improving Functional Prediction.[J]. ACS synthetic biology, 2022, 11 (7):

28. Sun YS(Sun, Yunsheng), Li DJ (Li, Dianjie), Ni CJ (Ni, Congjian), Ge YD (Ge, Yingda), Qian H (Qian, Hong), Ouyang Q (Ouyang, Qi), Li FT (Li, Fangting). ATP hydrolysis kinetics and thermodynamics as determinants of calcium oscillation in pancreatic β cells[J]. Physical Review Research, 2022, 4(4): 043142.

29. Zhang Fengyu,Sun Yanhong,Zhang Yihao,Shen Wenting,Wang Shujing,Ouyang Qi,Luo Chunxiong.Independent control of amplitude and period in a synthetic oscillator circuit with modified repressilator[J].Communications Biology,2022,5(1):23-23.

30. Han Xu,Wu Zhaolong, Yang Tian, Ouyang Qi,Cryo-EM Data Statistics and Theoretical Analysis of KaiC Hexamer[J]. Chinese Physics Letters, 2022, 39 (7):

31. Li Xiao, Jin Yiteng, Shi Jialin, Sun Xiaoqiang, Ouyang Qi, Luo Chunxiong. A high throughput microfluidic system with large ranges of applied pressures for measuring the mechanical properties of single fixed cells and differentiated cells.[J]. Biomicrofluidics, 2022, 16 (3): 034102-034102.

32. Wu Di, Wang Hongli, Ouyang Qi. Robust network topologies for temperature-inducible bioswitches[J]. Journal of Biological Engineering, 2022, 16 (1):

33. Li Jun, Yu Daqi, Liu Lan, Liang Huanhuan, Ouyang Qi, Liu Yingfang. Structural study of the N-terminal domain of human MCM8/9 complex.[J]. Structure (London, England : 1993), 2021, 29 (10): 1171-1181.e4.

34. Zhang Dongliang, Ouyang Qi. Nonequilibrium Thermodynamics in Biochemical Systems and Its Application[J]. Entropy, 2021, 23 (3): 271-271.

35. Shen Wenting, Gao Ziqing, Chen Kaiyue, Ouyang Qi, Luo Chunxiong. Yeast cells under glucose-limitation environment need increased response cost for osmostress defense[J]. bioRxiv, 2021: 2021.06. 24.449709.

36. Y.H. Zhang, Y. Wang, C.B. Lou, Qi Ouyang, L. Qian Paired dCas9 design as a nucleic acid detection platform for pathogenic strains. Methods (2021). DOI: 10.1016/j.ymeth.2021.06.003

37. P.J. Zhou, X. Gao, X.L. Li, L.X. Li, C.Y. Niu, Qi Ouyang , H.Q. Lou, T.J. Li , F.T. Li, Stochasticity Triggers Activation of the S-phase Checkpoint Pathway in Budding Yeast, PRX，11, (2021) 011004, pp1-23.

38. Cai Chenjing, Wang Shiwei, Xu Youjun, Zhang Weilin, Tang Ke, Ouyang Qi, Lai Luhua, Pei Jianfeng. Transfer Learning for Drug Discovery.[J]. Journal of medicinal chemistry, 2020, 63 (16): 8683-8694.

39. Y.M. Dong, F.J. Sun, Z. Ping, Qi Ouyang, L. Qian. DNA storage: research landscape and future prospects，National Science Review 7, (2020)1092–1107.

40. X. Zhang, D.Q. Yu, J.C Sun, Y.H Wang, Qi Ouyang, T. Wang, Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis, Structure 28, (2020) 555–561.

41. Y. Zhao, D.D Wang, Z.W. Zhang, Y. Lu,3 X.J. Yang, Qi Ouyang, C. Tang, and F.T. Li, Critical slowing down and attractive manifold: A mechanism for dynamic robustness in the yeast cell-cycle process, PRE, 101, (2020) 042405, 1-23

42. K.Y. Chen, W.T. Shen, Z.W. Zhang, F.Z. Xiong, Qi Ouyang, C.X. Luo, Age‑dependent decline in stress response capacity revealed by proteins dynamics analysis, Scientific Reports, 10 (2020) 15211.| https://doi.org/10.1038/s41598-020- 72167-4.

43. C.Y. Lu, J. Xu, J.T. Han, X. Li, N.T. Xue, J.S. Li, W.H. Wu, X.L. Sun, Y.G. Wang, Qi Ouyang, G. Yang, Chunxiong Luo, A novel microfluidic device integrating focusseparation speed reduction design and trap arrays for high-throughput capture of circulating tumor cells, Lab on Chip, （2020）DOI: 10.1039/d0lc00631a.

44. Z.Q. Gao, J. Xu, K.Y. Chen, S.J. Wang, Qi Ouyang, and C.X. Luo, Comparative Analysis of Yeast Replicative Lifespan in Different Trapping Structures Using an Integrated Microfluidic System, Adv. Mater. Technol. (2020), 2000655 DOI: 10.1002/admt.202000655.

45. K. Zou, S. Rouskin, K. Dervishi, M. A. McCormick, A. Sasikumar, C. Deng, Z. Chen,M. Kaeberlein, R. B. Brem, M. Polymenis, B. K. Kennedy, J. S. Weissman, J. Zheng, Q. Ouyang H. Li, Life span extension by glucose restriction is abrogated by methionine supplementation Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span. Sci. Adv. 6, (2020) eaba1306. DOI: 10.1126/sciadv.aba1306

46. L.J. Li, T.Wu, Y. Wang, M. Ran, Y. Kang, Q Ouyang, C.X. Long, Spatial coordination in a mutually beneficial bacterial community enhances its antibiotic resistance, Commun. Biol. 3 (2019) 301. doi:10.1038/s42003-019-0533-0.

47. D.L. Zhang, Y.S. Cao, Qi Ouyang, Y.H. Tu, The energy cost and optimal design for synchronization of coupled molecular oscillators, Nature Physics,16 (2019) 95-100. doi:10.1038/s41567-019-0701-7.

48. L.L.Wu. H.L. Wang*, Qi Ouyang*, Constructing network topologies for multiple signal-encoding functions, BMC Sys. Biol. 13(6) (2019). https://doi.org/10.1186/ s1298-018-0675-5

49. X.Q. Zhang, G.W. Si, Y.M. Dong, K.Y Chen, Qi Ouyang, C.X. Luo, Y.H. Tu, Escape band in Eschrichia Coli chemotaxis in opposing attractant and nutrient gradients, PNAS, 116 (2019) 2253-2258. www.pnas.org/cgi/doi/10.1073/pnas/808200116.