教授，博士生导师。理学博士(华东师范大学)，博士后研究(东京工业大学)。2002年10月至2021年1月，中国科学院化学研究所工作，研究员，博士生导师；2021年1月起，北京师范大学化学学院工作，教授，博士生导师。曾获国家杰出青年科学基金资助、入选国家“万人计划”科技创新领军人才、主持完成基金委创新群体、重大等项目。以第一完成人身份，曾获国家自然科学二等奖、北京市科学技术一等奖等。
研究兴趣
活体分析化学
电分析化学
脑化学检测与调控
代表性论文
1. Lai, J.; Liu, S.; Ma, W.; Wu, F.; Yu, F.; Yu, P.; Mao, L., Steric effect ofintermediates inducesformation of three-dimensional covalentorganic frameworks. Nat. Commun. 2025, 16, 6071.
2. Li, S.; Xue, Y.; Sun, Z.; Wei, H.; Wu, F.; Mao, L., A Chemistry-Informed Generative Deep Learning Approach for Enhancing Voltammetric Neurochemical Sensing in Living Mouse Brain. J. Am. Chem. Soc. 2025, 147, 16804.
3. Ma, W.; Zhao, G.; Liu, R.; Li, K.; Wu, W.; Liu, J.; He, X.; Hou, L.; Yu, P.; Mao, L., Direct Quantification of Neuroprotective Effect of Single-Atom Catalyst on Neurochemical Transmission by Multi-Spatiotemporal Electrochemistry. Angew. Chem. Int. Ed. 2025, 64, e202502163.
4. Liu, R.; Zhang, S.; Ren, G.; Jin, P.; Zeng, H.; Yin, Y.; Wang, T.; Zhang, M.; Mao, L., Encapsulating Ionophores in Zeolite Imidazolate Framework-8 for Long-Term Monitoring of Ion Fluctuations in Living Rat Brain. Angew. Chem. Int. Ed. 2025, e202501901.
5. Wang, J.; Jiang, Y.; Xiong, T.; Lu, J.; He, X.; Yu, P.; Mao, L., Optically Modulated Nanofluidic Ionic Transistor for Neuromorphic Functions. Angew. Chem. Int. Ed. 2025, 64, e202418949.
6. Liu, J.; Jiang, Y.; Liu, R.; Jin, J.; Wei, S.; Ji, W.; He, X.; Wu, F.; Yu, P.; Mao, L., Vitamin C Drives Reentrant Actin Phase Transition: Biphasic Exocytosis Regulation Revealed by Single-Vesicle Electrochemistry. J. Am. Chem. Soc. 2024, 146, 17747.
7. Gao, X.; Wei, H.; Ma, W.; Wu, W.; Ji, W.; Mao, J.; Yu, P.; Mao, L., Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst. Nat. Commun.2024, 15, 7915.
8. Wei, S.; Ma, W.; Sun, M.; Xiang, P.; Tian, Z.; Mao, L.; Gao, L.; Li, Y., Atom-pair engineering of single-atom nanozyme for boosting peroxidase-like activity. Nat. Commun.2024, 15, 6888.
9. Zhang, L.; Yi, W.; Li, J.; Wei, G.; Xi, G.; Mao, L., Surfactant-free interfacial growth of graphdiyne hollow microspheres and the mechanistic origin of their SERS activity. Nat Commun 2023, 14, 6318.
10. Wei, S.; Wu, F.; Liu, J.; Ji, W.; He, X.; Liu, R.; Yu, P.; Mao, L., Direct Quantification of Nanoplastics Neurotoxicity by Single-Vesicle Electrochemistry. Angew. Chem. Int. Ed. 2023, 62, e202315681.
11. Zhu, F.; Xue, Y.; Ji, W.; Li, X.; Ma, W.; Yu, P.; Jiang, Y.; Mao, L. Galvanic Redox Potentiometry for Fouling-Free and Stable Serotonin Sensing in a Living Animal Brain. Angew. Chem. Int. Ed. 2023, 62, e202212458.
12. Zhou, Y.; Xiong, T.; Lu, J.; Yu, P.; Jiang, Y.; Xia, F.; Mao, L. Highly-Efficient Ion Gating through Self-Assembled Two-Dimensional Photothermal Metal-Organic Framework Membrane. Angew. Chem. Int. Ed. 2023, 62, e202302997.
13. Xiong, T.; Li, C.; He, X.; Xie, B.; Zong, J.; Jiang, Y.; Ma, W.; Wu, F.; Fei, J.; Yu, P.; Mao, L. Neuromorphic functions with a polyelectrolyte-confined fluidic memristor. Science 2023, 379, 156.
14. Wu, F.; Yu, P.; Mao, L. Multi-Spatiotemporal Probing of Neurochemical Events by Advanced Electrochemical Sensing Methods. Angew. Chem. Int. Ed. 2022, 62, e202208872.
15. Yang, X.; Wu, W.; Chen, X.; Wu, F.; Fan, S.; Yu, P.; Mao, L. A Versatile Artificial Metalloenzyme Scaffold Enabling Direct Bioelectrocatalysis in Solution, Sci. Adv. 2022, 8, eabo3315.
16. Yue, Q.; Wang, K.; Guan, M.; Zhao, Z.; Li, X.; Yu, P.; Mao, L. Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117596.
17. Pan, C.; Wu, F.; Mao, J.; Wu, W.; Zhao, G.; Ji, W.; Ma, W.; Yu, P.; Mao, L. Highly Stable and Selective Sensing of Hydrogen Sulfide in Living Mouse Brain with NiN4 Single-Atom Catalyst-Based Galvanic Redox Potentiometry. J. Am. Chem. Soc. 2022, 144, 14678.
18. Li, X.; Jin, Y.; Zhu, F.; Liu, R.; Jiang, Y.; Jiang, Y.; Mao, L. Electrochemical Conjugation of Aptamers on a Carbon Fiber Microelectrode Enables Highly Stable and Selective In Vivo Neurosensing. Angew. Chem. Int. Ed. 2022, 61, e202208121.
19. Li, W.; Jin, J.; Xiong, T.; Yu, P.; Mao, L. Fast-Scanning Potential-Gated Organic Electrochemical Transistors for Highly Sensitive Sensing of Dopamine in Living Rat Brain. Angew. Chem. Int. Ed. 2022, 61, e202204134.
20. Jin, J.; Mao, J.; Wu, W.; Jiang, Y.; Ma, W.; Yu, P.; Mao, L. Highly Efficient Electrosynthesis of Nitric Oxide for Biomedical Applications. Angew. Chem. Int. Ed. 2022, 61, e202210980.
21. Xue, Y.; Ji, W.; Jiang, Y.; Yu, P.; Mao, L. Deep Learning for Voltammetric Sensing in a Living Animal Brain. Angew. Chem. Int. Ed. 2021, 60, 23777.
22. Zhou, M.; Jiang, Y.; Wang, G.; Wu, W.; Chen, W.; Yu, P.; Lin, Y.; Mao, J.; Mao, L. Single-atom Ni-N-4 provides a robust cellular NO sensor. Nat. Commun. 2020, 11, 3188.
23. Yue, Q.; Li, X.; Wu, F.; Ji, W.; Zhang, Y.; Yu, P.; Zhang, M.; Ma, W.; Wang, M.; Mao, L. Unveiling the Role of DJ-1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro-Tip Electrodes. Angew. Chem.Int. Ed. 2020, 59, 11061.
24. Yu, P.; Wei, H.; Zhong, P.; Xue, Y.; Wu, F.; Liu, Y.; Fei, J.; Mao, L. Single-Carbon-Fiber-Powered Microsensor for In Vivo Neurochemical Sensing with High Neuronal Compatibility. Angew. Chem. Int. Ed. 2020, 59, 22652.
25. Wu, F.; Pan, C.; He, C.; Han, Y.; Ma, W.; Wei, H.; Ji, W.; Chen, W.; Mao, J.; Yu, P.; Wang, D.; Mao, L.; Li, Y. Single-Atom Co-N4 Electrocatalyst Enabling Four-Electron Oxygen Reduction with Enhanced Hydrogen Peroxide Tolerance for Selective Sensing. J. Am. Chem. Soc. 2020, 142, 16861.
26. Jin, J.; Ji, W.; Li, L.; Zhao, G.; Wu, W.; Wei, H.; Ma, F.; Jiang, Y.; Mao, L. Electrochemically Probing Dynamics of Ascorbate during Cytotoxic Edema in Living Rat Brain. J. Am. Chem. Soc. 2020, 142, 19012.
27. Guo, S.; Yu, P.; Li, W.; Yi, Y.; Wu, F.; Mao, L. Electron Hopping by Interfacing Semiconducting Graphdiyne Nanosheets and Redox Molecules for Selective Electrocatalysis. J. Am. Chem. Soc. 2020, 142, 2074.
28. Jiang, Y.; Ma, W.; Qiao, Y.; Xue, Y.; Lu, J.; Gao, J.; Liu, N.; Wu, F.; Yu, P.; Jiang, L.; Mao, L. Metal-Organic Framework Membrane Nanopores as Biomimetic Photoresponsive Ion Channels and Photodriven Ion Pumps. Angew. Chem. Int. Ed. 2020, 59, 12795.
29. Yang, X.; Tang, Q.; Jiang, Y.; Zhang, M.; Wang, M.; Mao, L. Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing. J. Am. Chem. Soc. 2019, 141, 3782.
30. Xiao, T.; Wang, Y.; Wei, H.; Yu, P.; Jiang, Y.; Mao, L. Electrochemical Monitoring of Propagative Fluctuation of Ascorbate in the Live Rat Brain during Spreading Depolarization. Angew. Chem. Int. Ed. 2019, 58, 6616.
全部服务领域
教授，博士生导师。理学博士(华东师范大学)，博士后研究(东京工业大学)。2002年10月至2021年1月，中国科学院化学研究所工作，研究员，博士生导师；2021年1月起，北京师范大学化学学院工作，教授，博士生导师。曾获国家杰出青年科学基金资助、入选国家“万人计划”科技创新领军人才、主持完成基金委创新群体、重大等项目。以第一完成人身份，曾获国家自然科学二等奖、北京市科学技术一等奖等。
研究兴趣
活体分析化学
电分析化学
脑化学检测与调控
代表性论文
1. Lai, J.; Liu, S.; Ma, W.; Wu, F.; Yu, F.; Yu, P.; Mao, L., Steric effect ofintermediates inducesformation of three-dimensional covalentorganic frameworks. Nat. Commun. 2025, 16, 6071.
2. Li, S.; Xue, Y.; Sun, Z.; Wei, H.; Wu, F.; Mao, L., A Chemistry-Informed Generative Deep Learning Approach for Enhancing Voltammetric Neurochemical Sensing in Living Mouse Brain. J. Am. Chem. Soc. 2025, 147, 16804.
3. Ma, W.; Zhao, G.; Liu, R.; Li, K.; Wu, W.; Liu, J.; He, X.; Hou, L.; Yu, P.; Mao, L., Direct Quantification of Neuroprotective Effect of Single-Atom Catalyst on Neurochemical Transmission by Multi-Spatiotemporal Electrochemistry. Angew. Chem. Int. Ed. 2025, 64, e202502163.
4. Liu, R.; Zhang, S.; Ren, G.; Jin, P.; Zeng, H.; Yin, Y.; Wang, T.; Zhang, M.; Mao, L., Encapsulating Ionophores in Zeolite Imidazolate Framework-8 for Long-Term Monitoring of Ion Fluctuations in Living Rat Brain. Angew. Chem. Int. Ed. 2025, e202501901.
5. Wang, J.; Jiang, Y.; Xiong, T.; Lu, J.; He, X.; Yu, P.; Mao, L., Optically Modulated Nanofluidic Ionic Transistor for Neuromorphic Functions. Angew. Chem. Int. Ed. 2025, 64, e202418949.
6. Liu, J.; Jiang, Y.; Liu, R.; Jin, J.; Wei, S.; Ji, W.; He, X.; Wu, F.; Yu, P.; Mao, L., Vitamin C Drives Reentrant Actin Phase Transition: Biphasic Exocytosis Regulation Revealed by Single-Vesicle Electrochemistry. J. Am. Chem. Soc. 2024, 146, 17747.
7. Gao, X.; Wei, H.; Ma, W.; Wu, W.; Ji, W.; Mao, J.; Yu, P.; Mao, L., Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst. Nat. Commun.2024, 15, 7915.
8. Wei, S.; Ma, W.; Sun, M.; Xiang, P.; Tian, Z.; Mao, L.; Gao, L.; Li, Y., Atom-pair engineering of single-atom nanozyme for boosting peroxidase-like activity. Nat. Commun.2024, 15, 6888.
9. Zhang, L.; Yi, W.; Li, J.; Wei, G.; Xi, G.; Mao, L., Surfactant-free interfacial growth of graphdiyne hollow microspheres and the mechanistic origin of their SERS activity. Nat Commun 2023, 14, 6318.
10. Wei, S.; Wu, F.; Liu, J.; Ji, W.; He, X.; Liu, R.; Yu, P.; Mao, L., Direct Quantification of Nanoplastics Neurotoxicity by Single-Vesicle Electrochemistry. Angew. Chem. Int. Ed. 2023, 62, e202315681.
11. Zhu, F.; Xue, Y.; Ji, W.; Li, X.; Ma, W.; Yu, P.; Jiang, Y.; Mao, L. Galvanic Redox Potentiometry for Fouling-Free and Stable Serotonin Sensing in a Living Animal Brain. Angew. Chem. Int. Ed. 2023, 62, e202212458.
12. Zhou, Y.; Xiong, T.; Lu, J.; Yu, P.; Jiang, Y.; Xia, F.; Mao, L. Highly-Efficient Ion Gating through Self-Assembled Two-Dimensional Photothermal Metal-Organic Framework Membrane. Angew. Chem. Int. Ed. 2023, 62, e202302997.
13. Xiong, T.; Li, C.; He, X.; Xie, B.; Zong, J.; Jiang, Y.; Ma, W.; Wu, F.; Fei, J.; Yu, P.; Mao, L. Neuromorphic functions with a polyelectrolyte-confined fluidic memristor. Science 2023, 379, 156.
14. Wu, F.; Yu, P.; Mao, L. Multi-Spatiotemporal Probing of Neurochemical Events by Advanced Electrochemical Sensing Methods. Angew. Chem. Int. Ed. 2022, 62, e202208872.
15. Yang, X.; Wu, W.; Chen, X.; Wu, F.; Fan, S.; Yu, P.; Mao, L. A Versatile Artificial Metalloenzyme Scaffold Enabling Direct Bioelectrocatalysis in Solution, Sci. Adv. 2022, 8, eabo3315.
16. Yue, Q.; Wang, K.; Guan, M.; Zhao, Z.; Li, X.; Yu, P.; Mao, L. Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117596.
17. Pan, C.; Wu, F.; Mao, J.; Wu, W.; Zhao, G.; Ji, W.; Ma, W.; Yu, P.; Mao, L. Highly Stable and Selective Sensing of Hydrogen Sulfide in Living Mouse Brain with NiN4 Single-Atom Catalyst-Based Galvanic Redox Potentiometry. J. Am. Chem. Soc. 2022, 144, 14678.
18. Li, X.; Jin, Y.; Zhu, F.; Liu, R.; Jiang, Y.; Jiang, Y.; Mao, L. Electrochemical Conjugation of Aptamers on a Carbon Fiber Microelectrode Enables Highly Stable and Selective In Vivo Neurosensing. Angew. Chem. Int. Ed. 2022, 61, e202208121.
19. Li, W.; Jin, J.; Xiong, T.; Yu, P.; Mao, L. Fast-Scanning Potential-Gated Organic Electrochemical Transistors for Highly Sensitive Sensing of Dopamine in Living Rat Brain. Angew. Chem. Int. Ed. 2022, 61, e202204134.
20. Jin, J.; Mao, J.; Wu, W.; Jiang, Y.; Ma, W.; Yu, P.; Mao, L. Highly Efficient Electrosynthesis of Nitric Oxide for Biomedical Applications. Angew. Chem. Int. Ed. 2022, 61, e202210980.
21. Xue, Y.; Ji, W.; Jiang, Y.; Yu, P.; Mao, L. Deep Learning for Voltammetric Sensing in a Living Animal Brain. Angew. Chem. Int. Ed. 2021, 60, 23777.
22. Zhou, M.; Jiang, Y.; Wang, G.; Wu, W.; Chen, W.; Yu, P.; Lin, Y.; Mao, J.; Mao, L. Single-atom Ni-N-4 provides a robust cellular NO sensor. Nat. Commun. 2020, 11, 3188.
23. Yue, Q.; Li, X.; Wu, F.; Ji, W.; Zhang, Y.; Yu, P.; Zhang, M.; Ma, W.; Wang, M.; Mao, L. Unveiling the Role of DJ-1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro-Tip Electrodes. Angew. Chem.Int. Ed. 2020, 59, 11061.
24. Yu, P.; Wei, H.; Zhong, P.; Xue, Y.; Wu, F.; Liu, Y.; Fei, J.; Mao, L. Single-Carbon-Fiber-Powered Microsensor for In Vivo Neurochemical Sensing with High Neuronal Compatibility. Angew. Chem. Int. Ed. 2020, 59, 22652.
25. Wu, F.; Pan, C.; He, C.; Han, Y.; Ma, W.; Wei, H.; Ji, W.; Chen, W.; Mao, J.; Yu, P.; Wang, D.; Mao, L.; Li, Y. Single-Atom Co-N4 Electrocatalyst Enabling Four-Electron Oxygen Reduction with Enhanced Hydrogen Peroxide Tolerance for Selective Sensing. J. Am. Chem. Soc. 2020, 142, 16861.
26. Jin, J.; Ji, W.; Li, L.; Zhao, G.; Wu, W.; Wei, H.; Ma, F.; Jiang, Y.; Mao, L. Electrochemically Probing Dynamics of Ascorbate during Cytotoxic Edema in Living Rat Brain. J. Am. Chem. Soc. 2020, 142, 19012.
27. Guo, S.; Yu, P.; Li, W.; Yi, Y.; Wu, F.; Mao, L. Electron Hopping by Interfacing Semiconducting Graphdiyne Nanosheets and Redox Molecules for Selective Electrocatalysis. J. Am. Chem. Soc. 2020, 142, 2074.
28. Jiang, Y.; Ma, W.; Qiao, Y.; Xue, Y.; Lu, J.; Gao, J.; Liu, N.; Wu, F.; Yu, P.; Jiang, L.; Mao, L. Metal-Organic Framework Membrane Nanopores as Biomimetic Photoresponsive Ion Channels and Photodriven Ion Pumps. Angew. Chem. Int. Ed. 2020, 59, 12795.
29. Yang, X.; Tang, Q.; Jiang, Y.; Zhang, M.; Wang, M.; Mao, L. Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing. J. Am. Chem. Soc. 2019, 141, 3782.
30. Xiao, T.; Wang, Y.; Wei, H.; Yu, P.; Jiang, Y.; Mao, L. Electrochemical Monitoring of Propagative Fluctuation of Ascorbate in the Live Rat Brain during Spreading Depolarization. Angew. Chem. Int. Ed. 2019, 58, 6616.
