许国旺，男，博士，研究员。1991年在中国科学院大连化物所获理学博士学位，并留所在国家色谱研究分析中心工作。1995.10-1997.9获得马普(Max-Planck-Institut)研究基金在德国Tuebingen大学医学院工作。1997年9月底回国在大连化物所继续担任题目组长，97年11月提升为研究员。99年5月被聘为博士生导师。2004年获国家自然科学基金委杰出青年基金资助，2005年起担任代谢组学研究中心主任，2008年、2017年起分别担任中国科学院分离分析化学重点实验室副主任和主任，2016年-2023年11月担任大连化物所生物技术部常务副主任。现为中国化学会色谱专业委员会主任、中国抗癌协会肿瘤代谢委员会副主任、中国生物工程学会系统生物医学专业委员会副主任、中国化学会理事等。

2007-2014年曾任J. Chromatogr. B的editor，现正在担任TrAC的特约编辑，Metabolites副主编及Anal Chem（2021-2022）, Anal Chim Acta，J Proteome Res等10多个杂志编委。HPLC国际会议科学委员会常委。

已在PNAS, Nat Protoc, Nat Commun, Hepatology, Cell Metab, Diabetes Care, Cancer Res, Clin Chem, Anal Chem等杂志发表550多篇SCI文章，H-指数: 79（Web of Science Core Collection）、99 (Google)。发明专利授权超百件。一项成果获国家科技进步二等奖，一项获辽宁省科技发明二等奖，一项成果获中国分析测试协会科学技术成果特等奖。

    主要研究方向：主要研究方向：复杂样品分离分析方法的创新性研究；代谢组学、暴露组学分析技术平台及其在疾病、中药、植物表型、食品安全等方面应用的研究。

代表论著

1． Tianrun Xu, Hang Li, Peng Dou, Yuanyuan Luo, Siming Pu, Hua Mu, Zhihao Zhang, Disheng Feng, Xuesen Hu, Ting Wang, Guang Tan, Chuang Chen, Haiyang Li, Xianzhe Shi*, Chunxiu Hu*, Guowang Xu* (2024) Concentric Hybrid Nanoelectrospray Ionization‐Atmospheric Pressure Chemical Ionization Source for High‐Coverage Mass Spectrometry Analysis of Single‐Cell Metabolomics, Adv Sci, 11: e2306659.

2． Lei You#, Jing Kou#, Mengdie Wang#, Guoqin Ji#, Xiang Li, Chang Su, Fujian Zheng, Mingye Zhang, Yuting Wang, Tiantian Chen, Ting Li, Lina Zhou, Xianzhe Shi, Chunxia Zhao, Xinyu Liu*, Surong Mei*, Guowang Xu* (2024) An exposome atlas of serum reveals the risk of chronic diseases in the Chinese population, Nat Commun,15(1):2268

3． Yueqiong Ni#, Lingling Qian#, Sara Leal Siliceo#, Xiaoxue Long#, Emmanouil Nychas, Yan Liu, Marsena Jasiel Ismaiah, Howell Leung, Lei Zhang, Qiongmei Gao, Qian Wu, Lina Zhou, Xiaolin Wang, Qi Li, Hani El-Nezami, Aimin Xu, Guowang Xu*, Huating Li*, Gianni Panagiotou*, Weiping Jia* (2023) Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations, Cell Metab., 35, 1530–1547.

4． Zhen Ning#, Xin Guo#, Xiaolong Liu#, Chang Lu#, Aman Wang, Xiaolin Wang, Wen Wang, Huan Chen, Wangshu Qin, Xinyu Liu, Lina Zhou, Chi Ma, Jian Du, Zhikun Lin, Haifeng Luo, Wuxiyar Otkur, Huan Qi, Di Chen, Tian Xia, Jiwei Liu, Guang Tan*, Guowang Xu*, Hai-long Piao* (2022) USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma, Nat. Commun, 13(1): 2187. doi: 10.1038/s41467-022-29846-9.  

5． Fujian Zheng, Xinjie Zhao, Zhongda Zeng, Lichao Wang, Wangjie Lv, Qingqing Wang, Guowang Xu* (2020) Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, Nature Protocols, 15(8):2519-2537.

6． Di Yu#, Yang Liu#, Yiqiang Zhou, Guowang Xu#*, Chunzhang Yang#* (2020) Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism, Proc Natl Acad Sci U S A. 117(18):9964-9972.

7． Zujiang Yu,*, Jingjing Li, Ranran Sun, Yang Zhou, Qi Zhang, Qiongye Wang, Guangying Cui, Juan Li, Zhenfeng Duan, Xiaochao Ma, Yuming Xu, Zhichao Wang, Peiyuan Yin, Hailong Piao, Jun Lv, Xiaorui Liu, Yanfang Wang, Ming Fang, Zhengping Zhuang*, Guowang Xu*, Quancheng Kan* (2020) Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure, Advanced Science, 7, 1902996.

8． Ping Luo#, Peiyuan Yin#, Rui Hua#, Yexiong Tan, Zaifang Li#, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu*, Hongyang Wang*, Junqi Niu*, Guowang Xu* (2018) A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma, Hepatology, 67:662-675

9． Xinyu Liu, Miriam Hoene, Peiyuan Yin, Louise Fritsche, Peter Plomgaard, Jakob S. Hansen, Christos T. Nakas, Andreas M. Niess, Jens Hudemann, Michael Haap, Maimuna Mendy, Cora Weigert, Xiaolin Wang, Andreas Fritsche, Andreas Peter, Hans-Ulrich Häring, Guowang Xu*, Rainer Lehmann*(2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood, Clin. Chem., 64(5): 810–819

10． Shuangyuan Wang#, Zhichao Wang#, Lina Zhou, Xianzhe Shi*, Guowang Xu* (2017) Comprehensive analysis of short-, medium- and long-chain acyl-coenzyme As by on-line two dimensional liquid chromatography-mass spectrometry, Anal. Chem., 89(23):12902-12908